'Candidatus Endobugula sertula' is a symbiotic bacteria of Bugula neritinathat produces compounds known as bryostatins (Davidson et. al., 2001) which serve as chemical defense (via unpalatable taste) during larval stage of B. neritinaas they are not yet protected by a chitinous cuticle (Lindqist and Hay, 1996).Bryostatins are also studied for potential to treat Alzheimer's disease and some cancers (Kraft et. al., 1986, Parkinson et. al., 1994, Sun and Alkon 2005, 2006, Kuzirian et. al., 2006) . The localization of bryostatins and E. sertula during broodingshow that the symbiosis allows for delivery of the bryostatins and symbiont to ovicells and leads to implications for biochemical mechanisms of regulating symbiont growth and production of compounds. Researching those mechanisms will allow for better cultivation of E. sertula, which has proved to be diffcult in the lab, as well as improved understanding of host-microbe interactions(Sharp et. al., 2007).
Bugula neritina (commonly known as brown bryozoan or common bugula) is a cryptic species complex of sessile marine animal in the genus Bugula.[2]
It is invasive with a cosmopolitan distribution.[1]
Bugula neritina is of interest from a drug discovery perspective because its bacterial symbiont, Candidatus Endobugula sertula,[3] produces the bryostatins, a group of around twenty bioactive natural products. The bryostatins are under investigation for their therapeutic potential directed at cancer immunotherapy,[4][5] treatment of Alzheimer's disease,[5][6] and HIV/AIDS eradication,[7] due to their low toxicity and antineoplastic activity.[8]
The draft whole genome of Bugula neritina has recently been sequenced.[9] This adds to the growing number of genomes on the total list of sequenced animal genomes.
Bugula neritina is also of interest in materials science, where it is used as a model organism in biofouling studies.[10]
{{cite journal}}: Cite journal requires |journal= (help) Bugula neritina (commonly known as brown bryozoan or common bugula) is a cryptic species complex of sessile marine animal in the genus Bugula.
It is invasive with a cosmopolitan distribution.
Bugula neritina is of interest from a drug discovery perspective because its bacterial symbiont, Candidatus Endobugula sertula, produces the bryostatins, a group of around twenty bioactive natural products. The bryostatins are under investigation for their therapeutic potential directed at cancer immunotherapy, treatment of Alzheimer's disease, and HIV/AIDS eradication, due to their low toxicity and antineoplastic activity.
The draft whole genome of Bugula neritina has recently been sequenced. This adds to the growing number of genomes on the total list of sequenced animal genomes.
Bugula neritina is also of interest in materials science, where it is used as a model organism in biofouling studies.
Bugula neritina is een mosdiertjessoort uit de familie van de Bugulidae.[1] De wetenschappelijke naam van de soort is voor het eerst geldig gepubliceerd in 1758 door Linnaeus.
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フサコケムシ（総苔虫、学名: Bugula neritina）は、フサコケムシ属 (Bugula) に分類される付着性海洋動物の1種であるが、実際には複数の隠蔽種を含んでいる。フサコケムシは世界的に分布している侵入生物種である[1]。フサコケムシは生物活性天然物であるブリオスタチン類（およそ20の類縁体が確認されている）を生産するため、創薬の観点から興味を持たれている。ブリオスタチン類はがん[2][3]やアルツハイマー病[3][4]の治療薬としての可能性が研究されている。フサコケムシは、生物付着研究のモデル生物として、材料科学の分野でも興味が持たれている[5]。
この項目は、生物学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:生命科学／Portal:生物学）。 フサコケムシ（総苔虫、学名: Bugula neritina）は、フサコケムシ属 (Bugula) に分類される付着性海洋動物の1種であるが、実際には複数の隠蔽種を含んでいる。フサコケムシは世界的に分布している侵入生物種である。フサコケムシは生物活性天然物であるブリオスタチン類（およそ20の類縁体が確認されている）を生産するため、創薬の観点から興味を持たれている。ブリオスタチン類はがんやアルツハイマー病の治療薬としての可能性が研究されている。フサコケムシは、生物付着研究のモデル生物として、材料科学の分野でも興味が持たれている。
