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Phenuiviridae

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Phenuiviridae is a family of negative-strand RNA viruses in the order Bunyavirales.[1] Ruminants, camels, humans, and mosquitoes serve as natural hosts. Member genus Phlebovirus is the only genus of the family that has viruses that cause disease in humans (e.g. Rift Valley fever virus)[2] except Dabie bandavirus.[3]

Virology

Structure

Members of Phenuiviridae are enveloped viruses with helical capsid morphology. Envelope glycoproteins of these viruses are distributed with icosahedral symmetry (T=12).[2]

Genome

Phenuiviridae is a negative-sense single-stranded RNA virus family.[4] Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment.[1]

Some members of the family have ambisense gene encoding on the S segment (nucleocapsid proteins). The M segment includes envelope glycoproteins encoded in a polyprotein that is cleaved by host proteases.[5] Multiple different proteins can be encoded on the M segment due to leaky scanning by the ribosome.[2]

Life cycle

RNA transcripts are capped through cap snatching, but not polyadenylated.[5] Translation is terminated by a hairpin sequence at the end of each RNA transcript.[2]

Taxonomy

The following genera are recognized:[6]

References

  1. ^ a b "International Committee on Taxonomy of Viruses (ICTV)". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2018-02-02.
  2. ^ a b c d "Phenuiviridae ~ ViralZone".
  3. ^ Yu, Xue-Jie; Liang, Mi-Fang; Zhang, Shou-Yin; Liu, Yan; Li, Jian-Dong; Sun, Yu-Lan; Zhang, Lihong; Zhang, Quan-Fu; Popov, Vsevolod L.; Li, Chuan; Qu, Jing; Li, Qun; Zhang, Yan-Ping; Hai, Rong; Wu, Wei; Wang, Qin; Zhan, Fa-Xian; Wang, Xian-Jun; Kan, Biao; Wang, Shi-Wen; Wan, Kang-Lin; Jing, Huai-Qi; Lu, Jin-Xin; Yin, Wen-Wu; Zhou, Hang; Guan, Xu-Hua; Liu, Jia-Fa; Bi, Zhen-Qiang; Liu, Guo-Hua; Ren, Jun; Wang, Hua; Zhao, Zhuo; Song, Jing-Dong; He, Jin-Rong; Wan, Tao; Zhang, Jing-Shan; Fu, Xiu-Ping; Sun, Li-Na; Dong, Xiao-Ping; Feng, Zi-Jian; Yang, Wei-Zhong; Hong, Tao; Zhang, Yu; Walker, David H.; Wang, Yu; Li, De-Xin (21 April 2011). "Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China". New England Journal of Medicine. 364 (16): 1523–1532. doi:10.1056/NEJMoa1010095. PMC 3113718. PMID 21410387.
  4. ^ "Phenuiviridae".
  5. ^ a b Tercero, Breanna; Terasaki, Kaori; Nakagawa, Keisuke; Narayanan, Krishna; Makino, Shinji (October 2019). "A strand-specific real-time quantitative RT-PCR assay for distinguishing the genomic and antigenomic RNAs of Rift Valley fever phlebovirus". Journal of Virological Methods. 272: 113701. doi:10.1016/j.jviromet.2019.113701. PMC 6698219. PMID 31315022.
  6. ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 19 May 2021.
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Phenuiviridae: Brief Summary

provided by wikipedia EN

Phenuiviridae is a family of negative-strand RNA viruses in the order Bunyavirales. Ruminants, camels, humans, and mosquitoes serve as natural hosts. Member genus Phlebovirus is the only genus of the family that has viruses that cause disease in humans (e.g. Rift Valley fever virus) except Dabie bandavirus.

license
cc-by-sa-3.0
copyright
Wikipedia authors and editors
original
visit source
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wikipedia EN