The class Leotiomycetes contains numerous species with an anamorph placed within the fungi imperfecti (deuteromycota), that have only recently found their place in the phylogenetic system. The older classifications placed Leotiomycetes into the Discomycetes clade (inoperculate Discomycetes). Molecular studies have recently shed some new light to the still obscure systematics. Most scholars consider Leotiomycetes a sister taxon to Sordariomycetes in the phylogenetic tree of Pezizomycotina. Its division into subclasses have received strong support by the molecular data, but the overall monophyly of Leotiomycetes is dubious.
The order Lichinodiales and family Lichinodiaceae, newly circumscribed in 2019 to contain the genus cyanolichen genus Lichinodium, is the first known group of lichen-forming fungi in the Leotiomycetes. Family Lichinodiaceae was then placed in 2020 in the Leotiales order.
More orders were added in 2020, Lahmiales, Lauriomycetales, Marthamycetales, Medeolariales, Micraspidales and Phacidiales.