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Immunogenetic-Mechanisms-Driving-Norovirus-GII.4-Antigenic-Variation-ppat.1002705.g009

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Summary[edit] DescriptionAPI English: Bioinformatic approaches predicted five antibody epitopes on the surface of GII.4 noroviruses that appeared to be evolving over time and to correlate with the emergence of new GII.4 outbreak strains. Panel A: Amino acid variation of Epitopes A–E by GII.4 strain. Panel B: Predicted epitopes were expanded to include interacting amino acids within 8A. Epitope A (grey), Epitope B (blue), Epitope C (green), Epitope D (black), Epitope E (teal) and HBGA binding sites (magenta) mapped onto the P domain dimer of GII.4.2002. Date May 2012 Source Image file from Lindesmith L, Beltramello M, Donaldson E, Corti D, Swanstrom J, Debbink K, Lanzavecchia A, Baric R (2012). "Immunogenetic Mechanisms Driving Norovirus GII.4 Antigenic Variation". PLOS Pathogens. DOI:10.1371/journal.ppat.1002705. PMID 22615565. PMC: 3355092. Author Lindesmith L, Beltramello M, Donaldson E, Corti D, Swanstrom J, Debbink K, Lanzavecchia A, Baric R Permission
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Lindesmith L, Beltramello M, Donaldson E, Corti D, Swanstrom J, Debbink K, Lanzavecchia A, Baric R
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Lindesmith L, Beltramello M, Donaldson E, Corti D, Swanstrom J, Debbink K, Lanzavecchia A, Baric R
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Image file from journal (PLOS Pathogens). DOI (10.1371/journal.ppat.1002705).
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