Apoptotic Phagocytosis in C. elegans

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Description: English: A cell undergoing apoptosis displays transmembrane signals that may be recognized by another cell. The cell that recognizes the transmembrane signals begins to express the CED protein family. CED-2, CED-5 and CED-12 interact in a trimeric Guanine Nucleotide Exchange Factor (GEF), and activate CED-10, a Rac-GTPase. CED-10 then directly influences the polymerization of the actin cytoskeleton, promoting the phagocytic activity of the engulfing cell. Date: 21 April 2005. Source: http://www.wormbook.org/chapters/www_programcelldeath/pcdfig4.jpg. Author: Barbara Conradt, Ding Xue.