41598 2017 5824 Fig3 HTML

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Description: English: The double jelly-roll major capsid protein (MCP) of large icosahedral viruses. (A) Multiple sequence alignment of the MCPs of CroV, PBCV-1, PpV01 and APMV. Both CroV and APMV have large DE2 loops. (B) The CroV MCP (red) was homologously modeled and superposed with the X-ray structure of PBCV-1 (cyan) to show the longer DE2 loop of CroV. (C) Ribbon diagram of the trimeric homologously modeled CroV double jelly-roll MCP capsomer displaying a pseudo-hexagonal shape. Individual double jelly-roll MCPs are color-coded. (D) Central cross-section of the cryo-EM map of CroV superposed with that of PBCV-1. CroV not only has a larger virion diameter (3000 Å vs 1800 Å), its capsid layer is also thicker (105 Å vs 75 Å), which is consistent with the extended DE2 loop shown in panel (B). Date: 4 July 2017. Source: https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-017-05824-w/MediaObjects/41598_2017_5824_Fig3_HTML.jpg at https://www.nature.com/articles/s41598-017-05824-w doi:10.1038/s41598-017-05824-w . Author: Chuan Xiao, Matthias G. Fischer, Duer M. Bolotaulo, Nancy Ulloa-Rondeau, Gustavo A. Avila, Curtis A. Suttle. Other versions: .