Fgene-09-00595-g002

Kuvaus:

Description: English: A model of the different fates of vRNA of flaviviruses. vRNA is replicated by NS5 within the vesicle packets (VP) with the assistance of other nonstructural proteins. Using vRNA, the positive strand (red), as a template, the synthesis of the negative strand (black) by NS5 is depicted. Subsequently, several new copies of vRNA are produced from the dsRNA replication intermediate (not shown). Translation presumably occurs outside of VPs since ribosomes can be visualized adjacent to these structures. vRNA is proposed to exit VPs through a pore to be directly encapsidated and enveloped into juxtaposed ER budding structures. Finally, vRNA is partially degraded by cellular XRN1 which generate sfRNA. sfRNA regulates several host responses including innate immunity at the levels of signal transduction and ISG translation. Date: 4 December 2018. Source: Mazeaud C, Freppel W and Chatel-Chaix L (2018) The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis. Front. Genet. 9:595. doi: 10.3389/fgene.2018.00595 https://www.frontiersin.org/articles/10.3389/fgene.2018.00595/full. Author: Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix.